Participants: Talianidis, Strouboulis, Ragoussis

DNA binding transcription factors (TFs) play critical roles in initiating global changes in gene activity, be it activation or repression. The binding of TFs to target genes leads to the recruitment of co-factors which include chromatin remodeling and modification complexes. The regulation of gene target networks by specific TFs at different stages constitutes the transcriptional programs that direct cellular differentiation. The objective of this thematic part of the InteGeR ITN, is to address TF function in endoderm and erythroid cell differentiation by characterizing TF protein complexes, by identifying global gene target networks and changes in chromatin structure during differentiation and by exploring DNA binding affinities for specific TFs.

Specific projects:

•    Analysis of transcription factors and their role in the generation of the hepatic epigenome (Talianidis)
•    Transcriptional regulatory networks in erythroid cell differentiation (Strouboulis)
•    Quantitative analysis of transcription factor-DNA binding site affinities (Ragoussis)

Contribution of Industrial and Associated partners